Home Primary Care & Preventive Medicine Amphetamine or methylphenidate treatment for adolescents with AD/HD may cause psychosis

Amphetamine or methylphenidate treatment for adolescents with AD/HD may cause psychosis

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“Children and young adults with” attention-deficit/hyperactivity disorder (AD/HD) “who are treated with the stimulants amphetamine or methylphenidate face a small but significant risk of developing psychosis, with amphetamine products twice as likely to spark a problem,” researchers concluded. The study revealed that “among 110,923 patients getting amphetamine (Adderall, Adzenys XR-ODT, others), 237 subsequently received a psychosis diagnosis or 0.21 percent.” Meanwhile, “in the same-sized group prescribed methylphenidate (Concerta, Ritalin, Daytrana, others), there were 106 episodes or 0.10 percent,” the study revealed. According to HealthDay, 12 years ago, “the U.S. Food and Drug Administration required stimulant manufacturers to warn that their products might unexpectedly cause psychotic or manic symptoms.”

The findings were published online March 20 in the New England Journal of Medicine.

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